Elevations in blood lactate by exogenous infusion blunts exercise-stimulated whole body lipolysis in healthy individuals: a randomized controlled trial.
Ricardo Mora-Rodriguez, Diego Mora-Gonzalez, Alfonso Moreno-Cabañas et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial investigated the impact of elevated blood lactate on exercise-stimulated lipolysis in eight healthy individuals. Results showed that infusing sodium lactate during moderate-intensity exercise significantly blunted the increase in whole body lipolysis, with a reduction of 25% in Ra glycerol compared to saline infusion (7.9 ± 2.0 vs. 10.5 ± 2.2 µmol·kg -1 ·min -1; P = 0.014).
Key findings
- Lactate infusion during moderate exercise reduced Ra glycerol by 25% (7.9 ± 2.0 vs. 10.5 ± 2.2 µmol·kg -1 ·min -1; P = 0.014).
- Fat oxidation rates were similar between MOD + LACT and MOD trials (7.70 ± 2.02 vs. 7.38 ± 1.47 µmol·kg -1 ·min -1; P = 0.612).
- Ra glucose and plasma glucose were elevated during intense exercise but unaffected by lactate infusion.
- Lactate levels during exercise matched those seen in high-intensity conditions (4.31 ± 1.68 mM).
Why it matters
Understanding the role of lactate in exercise metabolism is crucial, as it may influence fat oxidation and lipolysis, particularly in individuals with metabolic disorders. This knowledge can inform exercise recommendations and interventions.