Efficacy of a Vapocoolant Spray in Reducing Pain During Capillary Glucose Testing: A Randomized Crossover Trial.
J Emerg MedJul 17, 2026 (epub)
Clinical ResearchEmergency Medicine
Emre Kudu, Faruk Danış
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In 30 seconds
This randomized controlled trial evaluated the efficacy of vapocoolant spray in reducing pain during capillary glucose testing in an emergency department setting. Among 77 patients, the median pain score was 29 mm with vapocoolant compared to 40 mm with placebo, indicating a significant pain reduction of 33.3% (p < 0.001).
Key findings
- Median VAS score was 29 mm with vapocoolant vs 40 mm with placebo.
- Vapocoolant spray reduced pain perception by 33.3% (IQR, 14.8%-47.3%, p < 0.001).
- All observed adverse effects were mild and transient.
Why it matters
Reducing pain during routine procedures like capillary glucose testing can enhance patient comfort and compliance in emergency settings, potentially improving overall care quality.