Prostate lymphoma uncovered during urological encounters: Diagnostic challenges and clinical outcomes in a case series with systematic review of the literature.
Daniel Ajabshir, Gurpremjit Singh, Aravindh Rathinam et al.
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From the abstract
Prostatic lymphoma is a rare malignancy that can clinically resemble benign prostatic hyperplasia (BPH) or adenocarcinoma, often delaying diagnosis. Primary prostatic lymphoma (PPL) comprises <0.1% of prostate tumors and non-Hodgkin lymphomas, whereas secondary involvement occurs more commonly in systemic disease.
Reported results
Seven patients (age range 47-89) were diagnosed with prostatic lymphoma. Presenting features included lower urinary tract symptoms, hematuria, urinary retention, pelvic pain, and systemic B symptoms. Histologic findings included diffuse large B-cell lymphoma (n = 3), chronic lymphocytic leukemia/small lymphocytic lymphoma (n = 2), low-grade B-cell lymphoma (n = 1), mucosa-associated lymphoid tissue (MALT) lymphoma…
Authors' conclusions
Prostatic lymphoma is a heterogeneous entity with presentations that overlap with those of common urologic conditions. Histopathologic confirmation is essential in patients with atypical features or poor response to BPH therapies. Early recognition and multidisciplinary coordination are vital.