Prognostic value of liver histology in steatotic liver disease: a systematic literature review and meta-analysis.
A Sidney Barritt, Anila Qasim, Yestle Kim et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between histologic liver fibrosis and clinical outcomes in patients with metabolic dysfunction-associated steatohepatitis (MASH) and steatotic liver disease (MASLD). The analysis included 32 studies, revealing that the risk of progression to cirrhosis was twofold higher in F3 versus F2 (2.05 [1.45, 2.90]) and over ten times higher for hepatic decompensation in F3-4 versus F0-2 (10.93 [6.31, 18.92]).
Key findings
- Risk of progression to cirrhosis was twofold higher in F3 versus F2 (2.05 [1.45, 2.90]).
- Risk of hepatic decompensation was over ten times higher in F3-4 versus F0-2 (10.93 [6.31, 18.92]).
- Higher fibrosis stage correlated with significantly increased risk of major adverse liver outcomes and all-cause mortality.
Why it matters
Understanding the prognostic value of liver fibrosis can help clinicians assess the risk of serious liver-related outcomes in patients with MASH and MASLD, potentially guiding management and treatment decisions.