Efficacy of different doses of oliceridine for Patient-Controlled Intravenous Analgesia in patients undergoing Total Laparoscopic Hysterectomy.
PLoS OneSep 3, 2026 (epub)
Jiaojiao Deng, Baobao Ma, Kaihua Wei et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy and safety of three doses of oliceridine (0.1, 0.35, and 0.5 mg/kg) for patient-controlled intravenous analgesia in patients undergoing total laparoscopic hysterectomy. The moderate-dose group (0.35 mg/kg) showed significant improvements in cough-pain scores and recovery outcomes, including shorter time to first flatus and ambulation, compared to lower and higher doses.
Key findings
- Moderate-dose oliceridine (0.35 mg/kg) improved cough-pain scores and bolus press attempts compared to the low-dose group (p < 0.0083).
- The moderate-dose group had the best recovery outcomes, with shorter time to first flatus and ambulation.
- The high-dose group (0.5 mg/kg) was associated with higher nausea and lower quality of recovery scores at 48 hours (p < 0.0083).
Why it matters
Understanding the optimal dosing of oliceridine for postoperative analgesia can enhance recovery and minimize adverse effects in surgical patients, which is crucial for improving patient outcomes and satisfaction.