Remimazolam versus sevoflurane for general anaesthesia: A meta-analysis with trial sequential analysis of haemodynamic and clinical outcomes.
Eur J AnaesthesiolSep 4, 2026 (epub)
Clinical ResearchAnesthesiology
Lara Terumi Takayama, Kevlin de Souza, David Abraham Batista da Hora et al.
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In 30 seconds
This meta-analysis compared remimazolam and sevoflurane for general anaesthesia, analyzing 12 RCTs with 739 patients. Remimazolam significantly reduced intraoperative hypotension (RR 0.38, 95% CI 0.25 to 0.57; P < 0.001) and showed a higher mean arterial pressure at 30 minutes post-surgery (mean difference 6.05 mmHg, P < 0.03).
Key findings
- Remimazolam reduced the risk of intraoperative hypotension compared to sevoflurane (RR 0.38).
- Mean arterial pressure was higher with remimazolam at 30 minutes after surgery (mean difference 6.05 mmHg).
- Heart rate was consistently higher with remimazolam at multiple time points.
- Remimazolam suggested a reduction in postoperative nausea and vomiting incidence up to 72 hours (RR 0.66).
Why it matters
Understanding the comparative safety and efficacy of anaesthetic agents is crucial for optimizing patient outcomes during surgery. This study highlights remimazolam's potential advantages in maintaining hemodynamic stability and reducing postoperative complications.