Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review.
Chery Ahn, Haein Seo, Dongmin Jo et al.
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Case in brief
A 61-year-old woman with stage IVB cervical squamous cell carcinoma presented with acute headache and diplopia during systemic chemotherapy. Brain MRI indicated leptomeningeal metastasis, confirmed by CSF cytology. An Ommaya reservoir was placed for intrathecal methotrexate therapy, leading to rapid neurological improvement and sustained clearance of malignant cells. Despite systemic disease progression, LM-related symptoms were well managed, and the patient survived for 8 months post-diagnosis.
Diagnostic / clinical pearl
Clinicians should consider leptomeningeal metastasis in cervical cancer patients presenting with new neurological symptoms, as timely intervention can lead to significant symptomatic relief.
Why it matters
This case underscores the potential effectiveness of intrathecal chemotherapy via an Ommaya reservoir in managing neurological symptoms associated with leptomeningeal metastasis.