Blood Bile Acids for Inflammatory Bowel Disease Diagnosis and Disease Activity Assessment: A Metabolomics Meta-Analysis.
J Proteome ResSep 4, 2026
Clinical ResearchGastroenterology
Nguyen Quang Thu, Vo Thuy An, Le Hoang Bach Dat et al.
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In 30 seconds
This meta-analysis examined blood bile acid (BA) profiles in inflammatory bowel disease (IBD) by analyzing 28 studies involving 5056 IBD patients and 1721 healthy controls. It found consistently lower levels of secondary BAs in IBD patients compared to controls, with specific acids like deoxycholic acid and glycodeoxycholic acid frequently decreased. The study design was a systematic review and meta-analysis.
Key findings
- Lower secondary BA levels were consistently observed in IBD patients compared to healthy controls.
- Deoxycholic acid and glycodeoxycholic acid were frequently decreased in IBD patients.
- Glycocholic acid was increased in certain comparisons among IBD patients.
- Differential expression of BA-related genes was noted in blood across IBD comparisons.
Why it matters
Understanding the alterations in blood bile acids can aid in the diagnosis and assessment of disease activity in IBD, potentially guiding future biomarker development.