Clinical Evidence of Skin Improvements With a Biologically Active Multimodal Topical Skin Treatment.
J Drugs DermatolSep 1, 2026
Clinical ResearchDermatology
Zein E Obagi, Raffi J Balian, Susan V Ramsey et al.
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In 30 seconds
This noncomparative clinical trial evaluated the effects of the Peptide Facial Refining Concentrate (ST26-PF-F1) on skin health in healthy females aged 45 and older over 12 weeks. Significant improvements were noted in fine lines, skin elasticity, and hydration, with expert evaluations showing enhancements in facial contour and sagging. Participants reported high satisfaction with the treatment.
Key findings
- Significant improvements in fine lines, skin elasticity, and hydration were observed at all time points.
- Expert evaluations showed enhancements in facial contour and sagging at all assessments.
- Confocal microscopy revealed improvements in dermal collagen fibers and skin texture by week 12.
- Participants reported overall satisfaction with the product and no treatment-related discomfort.
Why it matters
As the population ages, effective antiaging treatments are essential for improving skin health and appearance. This study provides evidence for a new topical treatment that may enhance skin quality and patient satisfaction.