Successful pregnancy after in vitro fertilization-embryo transfer in a patient with cytochrome P450 oxidoreductase deficiency and a double uterus: Case report.
Shimin Wang, Xiuping Zhang, Jiayao Chen et al.
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Case in brief
A 29-year-old woman with a history of 7 years of infertility was diagnosed with cytochrome P450 oxidoreductase deficiency and uterus didelphys. After unsuccessful ovulation induction, a modified protocol with metformin and glucocorticoids was implemented. This led to the successful transfer of a single frozen-thawed blastocyst, resulting in a healthy term delivery of a male neonate.
What made this case unusual
The case highlights successful pregnancy in a patient with both cytochrome P450 oxidoreductase deficiency and a double uterus, conditions that complicate reproductive outcomes.
Diagnostic / clinical pearl
Clinicians should consider the possibility of cytochrome P450 oxidoreductase deficiency in patients with infertility and polycystic ovary syndrome-like symptoms, especially when accompanied by reproductive tract anomalies.
Why it matters
This case underscores the importance of individualized treatment protocols in complex reproductive scenarios, particularly in patients with rare genetic disorders.