Acquired hemophilia a caused by complicated urinary tract infection due to flavobacterium odoratum: A case report and literature review.
Di Chen, Ping Yuan, Mingqiang Ren
✦ AI-curated · Sources linked
Case in brief
A male patient developed acquired hemophilia A (AHA) following ureteroscopic lithotripsy, presenting with hematuria, a right medial thigh hematoma, fever, and prolonged activated partial thromboplastin time (APTT). Diagnosis was confirmed with reduced FVIII:C and a factor VIII inhibitor. Treatment included doxycycline for a complicated urinary tract infection caused by Flavobacterium odoratum, and hemostatic control was achieved with activated prothrombin complex concentrate. The patient was discharged with resolved bleeding and normalized coagulation parameters.
What made this case unusual
This case is notable as it is the first reported instance of AHA associated with a Flavobacterium odoratum infection, highlighting a rare infectious trigger for this bleeding disorder.
Diagnostic / clinical pearl
Clinicians should consider acquired hemophilia A in patients with unexplained bleeding, especially those with indwelling urinary catheters and complicated infections.
Why it matters
Recognizing the potential for AHA in the context of specific infections can lead to timely diagnosis and management, ultimately improving patient outcomes.