The epidemiology of respiratory syncytial virus (RSV) in hospitalized children in Europe before the widespread implementation of new RSV prophylactic strategies: A systematic review and meta-analysis.
Maria M Berikopoulou, Danai K Giavasoglou, Argyro Konstantopoulou et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence of respiratory syncytial virus (RSV) in hospitalized children across Europe, focusing on data collected post-COVID-19 and prior to new prophylactic strategies. Among 66,065 children, the overall pooled RSV in-hospital positivity was 48% (95% CI: 41%-56%), with higher rates in infants (<12 months) at 69% compared to older children.
Key findings
- Overall pooled RSV in-hospital positivity was 48% (95% CI: 41%-56%).
- Positivity rates were 53% for 2021-2022, 49% for 2022-2023, and 62% for 2023-2024.
- Co-infections were detected in 17% of RSV-positive patients.
- 62% of RSV-positive patients required respiratory support.
Why it matters
Understanding the epidemiology of RSV in hospitalized children is crucial for clinicians to assess the burden of disease and the potential impact of new prophylactic strategies. This data serves as a baseline for future evaluations of RSV interventions.