Levamisole-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis in paediatric nephrotic syndrome: dose-dependent and idiosyncratic risks in paediatric patients.
Neha Thakur Rai, Narendra Rai
✦ AI-curated · Sources linked
Case in brief
Two pediatric cases of levamisole-induced vasculitis are reported, highlighting the risks associated with this medication in managing nephrotic syndrome. The first case involved a female child who developed multisystemic vasculitis after an accidental dose increase, while the second case presented with similar symptoms after prolonged stable therapy. Both cases showed anti-neutrophil cytoplasmic antibodies and resolved upon drug withdrawal.
Diagnostic / clinical pearl
Clinicians should be vigilant for signs of levamisole-induced autoimmunity in pediatric patients, as it can occur with both dose escalation and prolonged therapy.
Why it matters
These cases illustrate that levamisole-induced vasculitis can affect diverse pediatric populations, emphasizing the need for careful monitoring regardless of treatment context.