Effects of Acute Low- and Moderate-Dose Alcohol on Chronic Disease-Related Biomarkers in Healthy Light and Heavy Drinkers.
Mollie A Monnig, Samantha E Clark, Peter M Monti
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial examined the effects of low-dose (0.35 g/kg) and moderate-dose (0.60 g/kg) alcohol on disease-related biomarkers in 32 healthy adults, both light and heavy drinkers. The study found that heavy drinking status was linked to higher levels of several biomarkers, while moderate-dose alcohol increased sRAGE levels, indicating a potential compensatory response to inflammation. Notably, hsCRP was lower with low-dose alcohol compared to placebo.
Key findings
- Heavy drinking status was associated with higher levels of adiponectin, angiogenin, ICAM-1, LCN2, and sRAGE.
- Moderate-dose alcohol increased sRAGE, suggesting a compensatory response to inflammation.
- Low-dose alcohol resulted in lower hsCRP levels compared to placebo.
- MMP-7, MMP-9, and LCN2 showed time-dependent fluctuations independent of experimental condition.
Why it matters
Understanding how alcohol affects biomarkers related to chronic diseases can inform clinicians about the potential health risks associated with different levels of alcohol consumption, even in healthy individuals.