Somatostatin Receptor-Expressing Hibernoma Mimicking Malignancy on SSTR-PET in MEN1: A Diagnostic Pitfall.

Clin Nucl MedSep 8, 2026 (epub)
Case ReportNuclear MedicineRadiology (Diagnostic)Pathology (Anatomic & Clinical)Medical GeneticsOncology (Medical)

Daniel Rosok, Hubertus Hautzel, Stefanie Bertram et al.

✦ AI-curated · Sources linked

Case in brief

A 21-year-old woman with MEN1 underwent serial somatostatin receptor (SSTR) PET imaging after curative treatment of pancreatic neoplasia, which was in complete remission. An intramuscular lesion showed moderate SSTR expression and slow progressive growth. Heterogeneous enhancement and diffusion restriction on MRI raised concern for malignancy, but biopsy histopathology established the diagnosis of hibernoma, a benign tumor of brown adipose tissue.

What made this case unusual

The hibernoma expressed SSTR on PET, mimicking malignancy in a patient undergoing imaging surveillance for MEN1-associated pancreatic neoplasia.

Diagnostic / clinical pearl

SSTR uptake and concerning MRI features do not establish malignancy; correlate multimodality imaging with histopathology when an intramuscular lesion is suspicious.

Source

PubMed · PMID 42708194

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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