Anti-inflammatory agents after hip and shoulder arthroplasty: A systematic review and meta-analysis .
Pak J Pharm SciSep 9, 2026
Clinical ResearchOrthopedic Surgery
Huang Ling, Zhang Yu, Deng Shu
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of perioperative anti-inflammatory agents on postoperative outcomes in adults undergoing hip and shoulder arthroplasty. Analyzing nine randomized controlled trials with 800 patients, the study found that these interventions significantly reduced postoperative C-reactive protein and interleukin-6 levels, as well as pain and hospital stay duration.
Key findings
- Anti-inflammatory interventions reduced postoperative C-reactive protein by WMD=-32.18.
- Interleukin-6 levels decreased significantly with a WMD of -31.25.
- Rest pain was reduced with a WMD of -0.41.
- Hospital stay was shortened by a WMD of -0.54.
Why it matters
Understanding the impact of anti-inflammatory agents on postoperative recovery can help clinicians optimize pain management and enhance recovery protocols for patients undergoing hip and shoulder arthroplasty.