Immune-checkpoint inhibitor-induced bullous pemphigoid in patients with metastatic renal cell carcinoma: two case reports and systematic review of the literature.
Panagiotis Filis, Magnus Lindskog, Philip Curman et al.
✦ AI-curated · Sources linked
Case in brief
Two patients with metastatic renal cell carcinoma developed bullous pemphigoid after treatment with immune-checkpoint inhibitors. Both presented with tense bullae and vesiculobullous eruptions, confirmed by skin biopsy and immunological testing. Following immunosuppressive treatment, both patients showed improvement, highlighting the need for careful monitoring of skin reactions in patients receiving ICIs.
Diagnostic / clinical pearl
Clinicians should be vigilant for bullous pemphigoid in patients receiving immune-checkpoint inhibitors, especially after prolonged treatment, as early recognition can facilitate timely management.