Hyperpolarized [1-13C]-Pyruvate MRI Differentiates Benign Fibroma From High-grade Serous Carcinoma.
Malene Aastrup, Esben Søvsø Szocska Hansen, Katrine Fuglsang et al.
✦ AI-curated · Sources linked
Case in brief
Two women with suspected ovarian cancer underwent preoperative imaging using hyperpolarized [1-13C]-pyruvate MRI and FDG PET/CT. The first patient, with a right adnexal mass, showed limited FDG uptake and minimal lactate production, leading to a diagnosis of benign fibroma. The second patient exhibited extensive metabolically active tumors on FDG PET/CT, with hyperpolarized imaging revealing high lactate-to-pyruvate conversion, confirming high-grade serous carcinoma.
Diagnostic / clinical pearl
Hyperpolarized [1-13C]-pyruvate MRI can effectively differentiate between benign and malignant adnexal masses by assessing tumor glycolytic activity.
Why it matters
This case highlights the potential of hyperpolarized MRI as a complementary tool to traditional imaging methods in the preoperative evaluation of ovarian masses.