Demyelination in degenerative cervical myelopathy: a systematic review and meta-analysis of autopsy and imaging studies.

Neurosurg RevSep 9, 2026 (epub)
Clinical ResearchNeurologyNeurosurgeryOpen access

Mohamed Jalloh, Brendon Wang, Huy Truong et al.

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In 30 seconds

This systematic review and meta-analysis evaluated the prevalence of demyelination in degenerative cervical myelopathy (DCM) using autopsy and imaging studies. In 364 DCM patients, the pooled proportion of demyelination was 75.2%. Additionally, magnetization transfer ratio (MTR) was significantly reduced in the ventral column, indicating a correlation with clinical severity.

Key findings

  • The pooled proportion of demyelination in DCM patients was 75.2% (95% CI: 16.8-97.6).
  • MTR was significantly reduced in the ventral column with a pooled mean difference of -5.88 (95% CI: -9.00 to -2.77, p=0.0002).
  • A significant positive correlation was found between MTR and baseline neurological function (pooled r=0.38, 95% CI: 0.14-0.57).

Why it matters

Understanding the role of demyelination in DCM can enhance the comprehension of disease progression and inform potential therapeutic strategies. MTR may serve as a valuable biomarker for assessing clinical severity and monitoring disease changes.

Source

PubMed · PMID 42714693Free full text on PubMed Central

Published in Neurosurg Rev. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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