The efficacy of modified psychodynamic psychotherapy for patients with schizophrenia-spectrum disorders in Germany: a prospective, single-centre, assessor-blinded, parallel-group, randomised controlled trial.

Lancet PsychiatrySep 10, 2026
Clinical ResearchPsychiatry

Christiane Montag, Anna-Lena Bröcker, Samuel Bayer et al.

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In 30 seconds

This randomized controlled trial evaluated the efficacy of Modified Psychodynamic Psychotherapy for Schizophrenia (MPP-S) combined with treatment as usual (TAU) in 130 outpatients with schizophrenia-spectrum disorders in Germany. Results indicated significant improvements in psychosocial functioning, with adjusted between-group differences in Mini-ICF-APP scores of -3.45 at 24 months and -4.07 at 36 months, favoring the MPP-S group.

Key findings

  • Significant improvement in psychosocial functioning with MPP-S plus TAU compared to TAU alone.
  • Adjusted between-group difference in Mini-ICF-APP scores of -3.45 at 24 months.
  • Adjusted between-group difference in Mini-ICF-APP scores of -4.07 at 36 months.
  • Frequency of adverse events was similar between groups.

Why it matters

The study highlights the potential of psychodynamic psychotherapy to enhance psychosocial functioning in patients with schizophrenia-spectrum disorders, addressing a gap in standard care. This could inform treatment strategies and improve patient outcomes.

Source

Published in Lancet Psychiatry. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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