Clinical, Laboratory and Radiological Factors associated with posterior reversible encephalopathy syndrome (PRES) in patients with eclampsia or pre-eclampsia: a systematic review and meta-analysis.
Neurol SciSep 10, 2026 (epub)
Mahnoor Zafarullah, Pranjal Kumar Singh, Ahmed Harb et al.
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In 30 seconds
This systematic review and meta-analysis evaluated clinical and laboratory factors associated with posterior reversible encephalopathy syndrome (PRES) in patients with eclampsia or pre-eclampsia. The analysis included 28 studies, revealing a pooled PRES incidence of 38.68%. Key findings indicated elevated liver enzymes and lower platelet counts in affected patients, highlighting the need for improved early identification of this condition.
Key findings
- Pooled incidence of PRES was 38.68% (95% CI: 29.63-48.59).
- Patients with PRES had significantly higher ALT (MD 35.88 IU/L) and AST (MD 48.69 IU/L).
- Platelet counts were significantly lower in PRES patients (MD: -31.15×10⁹/L).
- Imaging findings showed involvement of the frontal (43.05%) and temporal lobes (20.33%).
Why it matters
Understanding the clinical and laboratory factors associated with PRES can enhance early detection and management in patients with eclampsia and pre-eclampsia, potentially improving maternal and fetal outcomes.