Autophagy activation in granulosa cells as a mechanism of astaxanthin action: evidence from a pilot randomised trial in PMOS-associated infertility.
Hum Fertil (Camb)Sep 10, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Arezoo Maleki-Hajiagha, Ashraf Aleyasin, Fardin Amidi
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In 30 seconds
This pilot randomized trial investigated the effects of astaxanthin (AST) on autophagy in granulosa cells among 50 women with PMOS-related infertility. AST supplementation significantly increased total oocyte yield and mature oocyte yield compared to placebo. The study highlights AST's potential role in enhancing oocyte competence and embryo quality through autophagy modulation.
Key findings
- AST increased autophagy-related gene 7 (ATG7) expression and enhanced autophagy flux.
- Total oocyte yield and mature oocyte yield were significantly higher with AST after adjustment.
- The top-ranking embryo rate was significantly higher in the AST group after adjustment.
Why it matters
Understanding the role of autophagy in ovarian function could inform treatment strategies for women with PMOS-related infertility. Enhancing oocyte quality and quantity may improve reproductive outcomes in this population.