Natural products targeting the molecular pathology of salivary gland mucoepidermoid carcinoma: A systematic review of In vitro studies.
Stella Marleen, Upik Anderiani Miskad, Muhammad Husni Cangara et al.
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In 30 seconds
This systematic review evaluated the antitumor effects of natural products on human mucoepidermoid carcinoma cell lines. Fourteen in vitro studies were included, revealing that these interventions impaired cell viability and induced apoptosis through mechanisms involving ERK/MAPK, Mcl-1, and STAT3. The findings suggest potential for natural products in developing new treatments for this cancer type.
Key findings
- Natural products impaired viability or proliferation in mucoepidermoid carcinoma cell lines.
- Interventions primarily induced apoptosis, evidenced by increased Annexin V/PI and sub-G1 fractions.
- Mcl-1 was the most frequently identified anti-apoptotic regulator across studies.
- Heterogeneity in compounds and methods limited comparisons of potency among candidates.
Why it matters
The limited treatment options for mucoepidermoid carcinoma highlight the need for new therapeutic strategies. Natural products may offer a promising avenue for developing effective treatments by targeting multiple molecular pathways involved in tumor survival.
What to keep in mind
Heterogeneity in compounds, concentrations, cell lines, and measurement methods hinders comparisons of potency among candidates.