Antibiotic-impregnated bone graft to prevent infection after total hip arthroplasty (ABOGRAFT): protocol for a randomised, double-blind, placebo-controlled trial.
Daphne Wezenberg, Nils P Hailer, Olof Sköldenberg et al.
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In 30 seconds
The ABOGRAFT trial is a multicenter, randomized, double-blind, placebo-controlled study aimed at evaluating the safety and efficacy of tobramycin and vancomycin-impregnated bone graft in preventing prosthetic joint infection (PJI) after total hip arthroplasty (THA) in 1100 patients. The primary outcome is the relative risk difference in time to reoperation due to infection or PJI.
Key findings
- The study aims for a clinically relevant risk reduction of at least 50% in PJI rates.
- Patients will be randomized in a 1:1 ratio to receive either antibiotic-impregnated or placebo bone graft.
- Primary analysis will utilize proportional hazard models to assess outcomes.
Why it matters
Prosthetic joint infections are a significant complication following total hip arthroplasty, leading to increased morbidity and healthcare costs. Effective prevention strategies, such as antibiotic-impregnated bone grafts, could improve patient outcomes and reduce the incidence of reoperations.