Outcomes of stereotactic radiosurgery for spine multiple myeloma-a systematic review.
Neurosurg RevSep 14, 2026 (epub)
Muhammad Izhar, Yusuke S Hori, Ahed H Kattaa et al.
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In 30 seconds
This systematic review assessed the outcomes of stereotactic radiosurgery (SRS) for spinal multiple myeloma, analyzing three retrospective studies involving 133 patients. The review found local control rates between 89.4% and 100%, with pain improvement in 41-88% of patients. Median follow-up ranged from 11.2 to 27.8 months.
Key findings
- Local control rates for SRS ranged from 89.4% to 100%.
- Pain improvement was reported in 41-88% of treated patients/sites.
- Neurological improvement occurred in 56-71.4% of patients with preexisting deficits.
- De novo vertebral fractures ranged from 3.6% to 7%.
Why it matters
Understanding the efficacy and safety of SRS for spinal multiple myeloma is crucial for clinicians considering treatment options that minimize damage to surrounding tissues while effectively managing disease symptoms.
What to keep in mind
The evidence is limited to small retrospective studies with heterogeneous reporting.