Health Literacy and Capecitabine Adherence in a Remote Monitoring Pilot Trial for Breast Cancer: Post Hoc Exploratory Analysis.
Samuel Hernandez, Jane Meisel, Gelareh Sadigh et al.
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In 30 seconds
This post hoc exploratory analysis of a randomized controlled trial examined the relationship between health literacy and capecitabine adherence in women with breast cancer. Among 28 participants, those with lower health literacy showed a predicted adherence of 87.5% in the remote patient monitoring (RPM) group compared to 65.5% in the enhanced usual care (EUC) group, a significant difference of +22.1 percentage points (P=.008).
Key findings
- Predicted adherence for lower health literacy participants was 87.5% in RPM vs 65.5% in EUC (difference: +22.1 percentage points, P=.008).
- Among higher health literacy participants, adherence was 89.9% in RPM vs 84.1% in EUC (difference: +5.7 percentage points, P=.29).
- Within the EUC group, adherence was 18.6 percentage points lower for lower health literacy participants (P=.01).
- The health literacy × randomized group interaction did not reach statistical significance (P=.09).
Why it matters
Understanding the impact of health literacy on medication adherence is crucial for optimizing cancer treatment. This study suggests that remote monitoring may enhance adherence, particularly for patients with lower health literacy, highlighting the need for tailored interventions.