Ultra high-density, 4096-channel intraoperative neurophysiological brain mapping for functional localization of the human central sulcus.
Alexandra Fink Skular, Gelana Tostaeva, Elton Ho et al.
✦ AI-curated · Sources linked
Case in brief
During resection of a right parafalcine meningioma in a 56-year-old man, four flexible 1024-electrode micro-ECoG arrays were used to record somatosensory evoked potentials from the peri-Rolandic cortex during stimulation of the contralateral median and ulnar nerves and individual fingers. The arrays yielded usable signals from 91.3% of channels. Dense amplitude maps showed stimulus-dependent phase-reversal contours, and automated classification recovered the expected motor and sensory organization, consistent with standard intraoperative localization. Digit responses were spatially differentiated despite substantial overlap. Responses were correlated across approximately 3–4 mm of cortex, limiting physiological resolution despite the 400 μm electrode pitch.
What made this case unusual
The four-array, 4096-channel configuration produced continuous two-dimensional phase-reversal boundaries within the recording field, rather than a polarity change inferred between adjacent contacts. The dense electrode spacing did not confer submillimeter physiological resolution because responses were correlated across approximately 3–4 mm.
Diagnostic / clinical pearl
High-density surface micro-ECoG can map stimulus-dependent phase reversals across the peri-Rolandic cortex during a standard neurosurgical exposure, but electrode pitch should not be mistaken for physiological spatial resolution.
Why it matters
This single-case deployment supports further evaluation of dense surface micro-ECoG for intraoperative mapping and chronic brain-computer interface applications.