Deep brain stimulation for Tourette syndrome: a systematic review and meta-analysis.
Shenshen Li, Haihua Wei, Zhirong Wei et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy of deep brain stimulation (DBS) for refractory Tourette syndrome (TS) across various brain targets. Analyzing 22 studies with 358 patients, the results showed a mean reduction in Yale Global Tic Severity Scale (YGTSS) scores from 69.19 to 35.88, indicating a 48% decrease in tic severity. The study highlights the effectiveness of DBS, particularly with anteromedial globus pallidus internus (amGPi) stimulation.
Key findings
- Mean YGTSS scores decreased from 69.19 ± 18.04 preoperatively to 35.88 ± 17.23 postoperatively.
- DBS led to a 48% reduction in YGTSS scores, indicating significant improvement in tic severity.
- YBOCS scores decreased from 17.38 ± 6.15 preoperatively to 9.16 ± 4.12 postoperatively, averaging a 47% reduction.
- amGPi stimulation showed significantly better benefits (SMD = 3.01, P < 0.00001) compared to pvlGPi.
Why it matters
The findings underscore the potential of DBS as a targeted intervention for managing refractory Tourette syndrome, offering significant symptom relief for both motor tics and obsessive-compulsive symptoms, which can enhance patient quality of life.