Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review.
Mol NeurobiolSep 15, 2026 (epub)
Ștefania-Maria Mocrei-Rebrean, Vlad Răzniceanu, Sebastian Romeo Pintilie et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review examined the role of non-coding RNAs (ncRNAs) in mitochondrial dysfunction associated with Alzheimer's disease (AD). It highlighted the dysregulation of various ncRNAs, including microRNAs and long non-coding RNAs, in AD models, linking them to critical mitochondrial processes. Notably, miR-140 and lncRNA NEAT1 were identified as key regulators of mitophagy.
Key findings
- Multiple ncRNAs, including miR-9 and miR-34a, are implicated in mitochondrial biogenesis in AD.
- miR-140 and lncRNA NEAT1 regulate mitophagy, showing clinical dysregulation in AD.
- ncRNAs like miR-21-5p and miR-148a-3p are involved in the mitochondrial apoptosis pathway.
- Several ncRNAs control mitochondrial dynamics, with miR-195 and miR-124 studied in AD patients.
Why it matters
Understanding the role of ncRNAs in mitochondrial dysfunction could provide insights into the pathophysiology of Alzheimer's disease and highlight potential biomarkers or therapeutic targets for intervention.