Effect of demographic characteristics on the outcome of prostate cancer salvage radiotherapy: Analysis from a randomized controlled trial.
CancerSep 15, 2026
Clinical ResearchOncology (Medical)
Ismaheel O Lawal, Ashesh B Jani, Subir Goyal et al.
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In 30 seconds
This randomized controlled trial examined the effects of demographic factors on salvage radiotherapy (sRT) outcomes in post-prostatectomy men with detectable PSA. The study found that African American men (AAM) had a higher failure-free survival (FFS) rate compared to men of other races (MOR), with rates of 72.8% vs 58.7% (p = .002).
Key findings
- AAM had a higher FFS rate than MOR, 72.8% vs 58.7% (p = .002).
- In arm A, AAM's FFS rate was 64.0% compared to 45.3% for MOR (p = .008).
- In arm B, FFS improved for both groups, with AAM at 81.5% and MOR at 73.0% (p = .131).
- AAM had lower socioeconomic status and higher allostatic load scores than MOR.
Why it matters
Understanding the impact of demographic characteristics on treatment outcomes can help clinicians tailor interventions and address disparities in care for prostate cancer patients, particularly in salvage radiotherapy settings.