Near-infrared autofluorescence parathyroid imaging during total thyroidectomy to reduce the rate of postoperative hypoparathyroidism: A prospective two-center randomized clinical trial with a comprehensive long-term follow-up.
SurgeryJul 16, 2026 (epub)
Amanda Oester Andersen, Anders Christensen, Eva Lykke et al.
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In 30 seconds
This prospective two-center randomized clinical trial evaluated the impact of near-infrared autofluorescence imaging on postoperative hypoparathyroidism rates in 189 total thyroidectomy patients. The study found no significant difference in hypoparathyroidism rates at 3 months (15.6% vs 16.9%, P = .97) or 12 months between the autofluorescence and control groups, despite improved parathyroid gland identification in the autofluorescence group.
Key findings
- No significant difference in hypoparathyroidism rates at 3 months: 15.6% vs 16.9%, P = .97.
- Parathyroid gland identification was significantly higher in the autofluorescence group: 3.1 vs 2.8, P = .045.
- A higher fraction of controls received calcium and vitamin D at 3 months: 71.8% vs 59.0%, P = .16.
Why it matters
Understanding the effectiveness of near-infrared autofluorescence imaging in reducing postoperative hypoparathyroidism is crucial for improving surgical outcomes and patient care in thyroid surgery.