Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial.
Ann MedSep 16, 2026 (epub)
Xiaoxiao Xu, Gang Wang, Xinyu Li et al.
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In 30 seconds
This multicentre, double-blind, randomized controlled trial investigates whether ephedrine is more effective than phenylephrine in reducing postoperative delirium in 1,084 elderly patients undergoing major non-cardiac, non-neurosurgical surgeries. The primary outcome is the incidence of postoperative delirium within 7 days post-surgery.
Key findings
- The study will enroll 1,084 elderly patients across seven hospitals in China.
- The primary outcome is the incidence of postoperative delirium within 7 days after surgery.
- Participants will receive either phenylephrine or ephedrine to maintain mean arterial pressure.
Why it matters
Understanding the impact of different vasopressors on postoperative delirium can guide anesthetic management in elderly patients, a population at higher risk for this complication.