Non-Meningothelial Mesenchymal Tumor of the Central Nervous System: Case Report and Literature Review.
Laura Bauluz, Sara Marcos-González, David Castanedo et al.
✦ AI-curated · Sources linked
Case in brief
A 40-year-old man presented with progressive left-sided paresthesia, leading to the discovery of a supratentorial non-meningothelial mesenchymal tumor (NMMT) via neuroimaging, which revealed a parasagittal mass. After gross total resection, histological analysis showed a myxoid proliferation with cortical and dural infiltration. Despite extensive molecular testing, including RNA sequencing, the case highlighted the diagnostic challenges associated with NMMTs.
What made this case unusual
The identification of a putative low-confidence SHISA5::BRAF fusion adds to the complexity of classifying NMMTs, as it lacks canonical alterations typically associated with these tumors.
Diagnostic / clinical pearl
Clinicians should be aware that non-meningothelial mesenchymal tumors can present diagnostic challenges due to overlapping morphology and nonspecific immunophenotypes, necessitating comprehensive histological and molecular evaluation.
Why it matters
This case emphasizes the potential for alternative oncogenic mechanisms in NMMTs, highlighting the need for ongoing research into their classification and management.