Prevalence of neuropsychiatric and seizure disorders in neurofibromatosis type 1: a systematic review and meta-analysis.
J NeurolSep 17, 2026 (epub)
Elena Moreno-Charco, Carlos Pascual-Morena, Celia Álvarez-Bueno et al.
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In 30 seconds
This systematic review and meta-analysis assessed the prevalence of neuropsychiatric and seizure disorders in patients with neurofibromatosis type 1 (NF1). The analysis included 50 studies, revealing that the prevalence of intellectual disability was 8%, autism spectrum disorder was 11%, and attention deficit hyperactivity disorder was 33%. Additionally, the prevalence of seizures was found to be 11%.
Key findings
- Intellectual disability prevalence in NF1 is 8% (95% CI 6-11).
- Attention deficit hyperactivity disorder prevalence in NF1 is 33% (95% CI 26-40).
- Seizures occur in 11% of NF1 patients (95% CI 8-14).
- Autism spectrum disorder prevalence in NF1 is 11% (95% CI 7-14).
Why it matters
Understanding the prevalence of neuropsychiatric and seizure disorders in NF1 is crucial for clinicians to implement appropriate screening and management strategies. This knowledge can enhance patient care and inform follow-up protocols.