Pathogenesis of the Holmes tremor due to cerebellar lesions: A case series with a narrative review.

J Neurol SciSep 6, 2026 (epub)
Case ReportNeurology

Masahiro Nakamura, Osamu Isono

✦ AI-curated · Sources linked

Case in brief

This report discusses two patients with Holmes tremor associated with cerebellar lesions. MRI findings in both patients indicated Wallerian degeneration of the dentato-rubro-thalamic pathway (DRTP) and suggested involvement of the dentato-rubro-olivary pathway (DROP). The findings indicate that disruption of these pathways may contribute to the development of tremor in this context.

Diagnostic / clinical pearl

Clinicians should consider the involvement of the dentato-rubro-thalamic and dentato-rubro-olivary pathways when evaluating patients with Holmes tremor linked to cerebellar lesions.

Source

PubMed · PMID 42753305

Published in J Neurol Sci. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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