Which changes in adolescents' knowledge, attitudes, and practices following a school-based intervention in France increase HPV vaccination uptake and intentions? A mediation analysis.
Amanda Munoz, Amandine Gagneux-Brunon, Anne-Sophie Le Duc-Banaszuk et al.
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In 30 seconds
This randomized controlled trial evaluated the impact of educational and motivational activities (EMM) on HPV vaccination uptake and intentions among 2758 adolescents aged 13 to 15 in France. EMM was associated with a significant increase in HPV vaccination uptake or intention (OR: 1.57, 95% CI: 1.02-2.41), highlighting the importance of improving attitudes towards vaccination.
Key findings
- EMM increased HPV vaccination uptake or intention with an odds ratio of 1.57.
- Improved attitudes towards the vaccine's benefit-risk balance had an indirect effect (OR IE: 1.14).
- Increased perceived vaccine safety (OR IE: 1.12) and accessibility (OR IE: 1.11) were significant mediators.
- Discussing HPV vaccination with friends (OR IE: 1.11) also mediated the effect of EMM.
Why it matters
Enhancing adolescents' knowledge, attitudes, and practices regarding HPV vaccination is crucial for increasing uptake rates. This study underscores the role of educational interventions in shaping positive perceptions about vaccination, which can lead to improved public health outcomes.