Indocyanine green fluorescence imaging in minimally invasive liver resection for colorectal liver metastases: lesion detection and surgical outcomes-a systematic review and meta-analysis.
Fengjie Han, Qingqing Wang, Guiming Shu
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In 30 seconds
This systematic review and meta-analysis evaluated the use of indocyanine green (ICG) fluorescence imaging during minimally invasive liver resection for colorectal liver metastases (CRLM). The analysis included 18 reports, revealing a patient-level R0 resection rate of 92.5% and a lesion-level R0 resection rate of 93.0%. The study highlights the feasibility of ICG imaging but notes insufficient evidence for its comparative advantage over conventional methods.
Key findings
- Patient-level R0 resection rate was 92.5% (95% CI 62.7-98.9%).
- Lesion-level R0 resection rate was 93.0% (95% CI 83.2-97.3%).
- Major morbidity occurred in 6.2% of patients (95% CI 3.1-11.8%).
- The only controlled comparison showed higher lesion-level R0 with ICG (odds ratio 5.65, 95% CI 1.02-31.48).
Why it matters
The findings suggest that ICG fluorescence imaging may enhance lesion visualization and surgical outcomes in CRLM resections. However, the lack of robust comparative evidence necessitates caution in its routine application.