The NF-κB pathway in inflammatory responses in preeclampsia: A systematic review and meta-analysis.
Medicine (Baltimore)Sep 18, 2026
Clinical ResearchObstetrics & Gynecology
Hui Zhang, Yanhua Nong, Meiqi Huang et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the role of the NF-κB pathway in inflammatory responses associated with preeclampsia, analyzing 15 studies. It found that patients with preeclampsia had significantly elevated systolic and diastolic blood pressure, as well as increased levels of TNF-α and NF-κB, indicating enhanced inflammation.
Key findings
- Systolic and diastolic blood pressure were significantly elevated in preeclampsia patients.
- TNF-α and NF-κB levels were significantly increased in preeclampsia.
- Interleukin-1 beta and IL-6 levels did not differ significantly, with IL-6 showing a nonsignificant trend toward increase.
Why it matters
Understanding the role of the NF-κB pathway in preeclampsia may help identify potential biomarkers and therapeutic targets, which could improve management strategies for this serious pregnancy complication.