Stroke secondary to cancer-associated coagulopathy: a systematic review.
J NeurolSep 20, 2026 (epub)
Clinical ResearchOncology (Medical)NeurologyRadiology (Diagnostic)Pathology (Anatomic & Clinical)Open access
Carlota Jauregui Larrañaga, Emilio Gómez Arteta, Juan Marta Enguita et al.
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In 30 seconds
This systematic review examined cancer-associated coagulopathy (CAC) as a cause of ischemic stroke in cancer patients, analyzing 82 studies. CAC-related strokes typically occur within six months of cancer diagnosis and are linked to advanced disease, with 30-day mortality rates ranging from 25 to 50%.
Key findings
- CAC-related stroke is associated with advanced or metastatic disease and a high risk of early recurrence.
- D-dimer is the biomarker most consistently linked to recurrence and mortality.
- Thirty-day mortality rates for CAC-related stroke range from 25 to 50%.
- Characteristic imaging findings include multiple infarcts in more than two vascular territories.
Why it matters
Understanding the unique features and risks associated with CAC-related strokes can aid clinicians in early recognition and management, potentially improving patient outcomes in this vulnerable population.