Male breast cancer in Arab populations: a systematic review of molecular, genetic, and clinicopathologic characteristics.
J Egypt Natl Canc InstSep 21, 2026 (epub)
Shaden Abunasser, Raghad Al-Taweel, Shahrazad Elnatsheh et al.
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In 30 seconds
This systematic review analyzed 54 studies involving 1,534 male breast cancer (MBC) patients from Arab countries, revealing that invasive ductal carcinoma is the most common subtype (92.6%). The majority of cases were luminal A (45.7%) and luminal B (40.9%), with high estrogen receptor (ER) positivity (71.5%) and low HER2 positivity (12.6%).
Key findings
- Invasive ductal carcinoma was the predominant histological subtype at 92.6%.
- Luminal A and B subtypes accounted for over 86% of cases among reported intrinsic subtypes.
- High ER positivity was observed in 71.5% of patients, while HER2 positivity was only 12.6%.
- Pathogenic truncating BRCA2 variants were the most frequently identified genetic alterations.
Why it matters
Understanding the molecular and genetic characteristics of male breast cancer in Arab populations is crucial for developing tailored management strategies. This knowledge can enhance personalized treatment approaches and improve patient outcomes.