Deep brain stimulation outcomes in pediatric drug-resistant epilepsy: A systematic review and meta-analysis.
SeizureSep 12, 2026 (epub)
Asmaa Mhanna, Michael A Ciliberto, Sreenath Thati Ganganna et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the long-term efficacy and safety of deep brain stimulation (DBS) in 149 pediatric patients with drug-resistant epilepsy (DRE). The study found a pooled responder rate of 63.3% for seizure reduction at ≥12 months, indicating that DBS can significantly reduce seizures in this population.
Key findings
- The pooled responder rate for seizure reduction at ≥12 months was 63.3%.
- Seizure freedom was achieved in 13.8% of patients at ≥12 months.
- Responder rates varied by stimulation target: 66.2% for CM, 46.2% for ANT, and 76.8% for STN.
Why it matters
The findings suggest that DBS can provide substantial long-term seizure reduction in children with DRE, which is crucial for improving quality of life. Understanding the efficacy and safety of this treatment can guide clinicians in managing challenging cases of epilepsy.