Modified single-stapled anastomosis in laparoscopic or robotic low anterior resection for rectal cancer: protocol for a multicentre randomised controlled trial.

In 30 seconds

This multicentre, parallel-group, superiority randomised controlled trial investigates the modified single-stapled technique (MST) versus the conventional double-stapled technique (DST) in 450 patients undergoing laparoscopic or robotic low anterior resection for rectal cancer. The primary outcome is anastomotic leakage within 30 days post-surgery, with the aim of determining if MST reduces this complication.

Key findings

• The primary outcome is anastomotic leakage within 30 days after surgery.
• The trial will include 450 patients randomised in a 1:1 ratio to MST or DST.
• Secondary outcomes include local recurrence and 3-year disease-free survival.

Why it matters

Anastomotic leakage is a significant complication following low anterior resection for rectal cancer. Understanding whether MST can reduce this risk may influence surgical techniques and improve patient outcomes.