Systemic light chain amyloidosis presenting as jejunal perforation.
Hung-Chih Chen, Ta-Chuan Yu, Keng-Man Chiang et al.
✦ AI-curated · Sources linked
Case in brief
A patient with recurrent uterine cancer presented with jejunal perforation, a rare complication of systemic light chain amyloidosis. Prior to perforation, she experienced postprandial abdominal distension for three years. The diagnosis was complicated by her cancer history, but the presence of amyloid fibrils was confirmed in her uterine cancer tissue. Management of her condition was challenging due to these comorbidities.
What made this case unusual
Jejunal perforation is an uncommon manifestation of systemic AL amyloidosis, particularly in the context of recurrent uterine cancer.
Diagnostic / clinical pearl
Clinicians should consider systemic AL amyloidosis in patients with gastrointestinal symptoms, especially when they have complex comorbidities like cancer.
Why it matters
Recognizing the gastrointestinal manifestations of AL amyloidosis can lead to earlier diagnosis and management, potentially improving patient outcomes.