Recovery of ovarian function after chemotherapy in premenopausal women with breast cancer: a systematic review and meta-analysis.
Breast Cancer Res TreatSep 22, 2026 (epub)
Phi Y Huynh, Binh V Tran, Vinh T Ngo et al.
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In 30 seconds
This systematic review and meta-analysis evaluated ovarian function recovery post-chemotherapy in 10,216 premenopausal women with breast cancer. The study found that the probability of recovery at 12, 24, and 60 months was 30.4%, 38.5%, and 43.4%, respectively, with a mean recovery time of 12.3 months.
Key findings
- Ovarian function recovery probabilities were 30.4% at 12 months and 43.4% at 60 months.
- Mean time to ovarian function recovery was 12.3 months.
- Older age and longer chemotherapy duration were associated with lower recovery probabilities.
- Higher pretreatment anti-Müllerian hormone levels may improve recovery, though not statistically significant.
Why it matters
Understanding the likelihood and timing of ovarian function recovery is crucial for clinicians to provide comprehensive counseling on reproductive risks and fertility preservation options for premenopausal women undergoing chemotherapy.