Combined Use of Etomidate and Propofol Reduce the Duration of Apnea vs Propofol Alone in Patients Undergoing Hysteroscopy: A Randomised Double-Blind Trial.
Yi Qin, Fan Ye, Teng Wang et al.
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From the abstract
The incidence of respiratory suppression remains high in outpatients receiving intravenous anesthesia for hysteroscopy, presenting a substantial risk to safety. Combined use of etomidate and propofol may reduce apnea duration compared with propofol alone.
Reported results
A total of 365 subjects were included with combination (n = 182) and propofol alone (n = 183). Patients in both groups were adequately sedated, and the combination was significantly non-inferior to propofol alone. Median apnea duration was significantly shorter in the combined group (73 s) than in the propofol group (116 s, difference, -43 s; P < 0.001).
Authors' conclusions
The combination of etomidate and propofol provides comparable sedative efficacy to propofol alone during hysteroscopy, while significantly shortening apnea duration induced by intravenous sedatives.