Efficacy and Safety of Three Needling Patterns for Microneedle Radiofrequency in Axillary Osmidrosis: A Prospective Randomized Trial.
J Vis ExpSep 22, 2026 (epub)
Clinical ResearchDermatology
Judan Zhong, Lin Liu, Jin Chen et al.
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In 30 seconds
This prospective randomized controlled trial evaluated the efficacy and safety of three microneedle radiofrequency (MNRF) needling patterns in 90 patients with moderate-to-severe axillary osmidrosis. The zone-directed (ZD) pattern achieved a clinical effectiveness of 90.0%, comparable to full longitudinal (FL) at 93.3%, while showing a better safety profile than full transverse (FT) needling, which had a lower efficacy of 53.3%.
Key findings
- The zone-directed needling pattern achieved 90.0% clinical effectiveness.
- Full longitudinal needling showed 93.3% efficacy but higher adverse reactions.
- Full transverse needling had a lower efficacy of 53.3% and a 40.7% recurrence rate.
- The optimized ZD pattern balances efficacy and safety in MNRF treatment.
Why it matters
Understanding the efficacy and safety of different needling patterns in MNRF can help clinicians optimize treatment protocols for axillary osmidrosis, potentially improving patient outcomes and satisfaction.