Photodynamic Diagnosis of Actinic Keratosis: A Systematic Review.
Acta Derm VenereolSep 23, 2026 (epub)
Clinical ResearchDermatology
Younes Kazbennaou, Marie Boileau, Cyril Maire et al.
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In 30 seconds
This systematic review evaluated the effectiveness of photodynamic diagnosis (PDD) for actinic keratosis (AK) across 37 studies. It found significant methodological heterogeneity, particularly in photosensitizer protocols and imaging systems. Methyl aminolevulinate (MAL) and aminolevulinic acid (ALA) were used in 54% and 51% of studies, respectively, with most studies employing a 3-hour protocol.
Key findings
- 54% of studies utilized methyl aminolevulinate (MAL) as a photosensitizer.
- 70% of studies followed a 3-hour incubation protocol for PDD.
- 89% of studies used excitation sources emitting light within the 400-410 nm range.
- 62% of studies described fluorescence quantification methods.
Why it matters
Understanding the variability in PDD methodologies for actinic keratosis is crucial for clinicians aiming to improve diagnostic accuracy and treatment assessment. Standardized protocols could enhance the reliability of PDD in clinical practice.