Low Prevalence of Exploratory Biochemical Patterns Compatible with Osteomalacia in a Large Cohort of Participants with Low Serum 25-Hydroxyvitamin D Levels.
Rolf Jorde, Per Medbøe Thorsby, Guri Grimnes
✦ AI-curated · Sources linked
In 30 seconds
This study investigated the prevalence of biochemical patterns indicative of osteomalacia in a cohort with low serum 25-hydroxyvitamin D levels. Conducted as a cross-sectional study followed by a randomized controlled trial, it included 423 participants initially, with 382 completing the trial. The findings revealed a low prevalence of 8.3% for biochemical patterns compatible with osteomalacia, and vitamin D supplementation significantly improved biochemical parameters compared to placebo.
Key findings
- The prevalence of biochemical patterns compatible with osteomalacia was 8.3%.
- Vitamin D supplementation significantly reduced plasma parathyroid hormone and alkaline phosphatase levels.
- Serum calcium levels increased significantly with vitamin D supplementation compared to placebo.
Why it matters
Understanding the biochemical patterns associated with osteomalacia in patients with low vitamin D levels is crucial for effective diagnosis and management. This study highlights the low prevalence of such patterns, which may influence clinical decision-making regarding vitamin D supplementation.