The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis.
Oladipupo Olalere, Min-Dee Koh, Katie Crabb et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome (PMOS). Analyzing 34 studies with 1,871 participants, the results indicated that lifestyle interventions significantly improved menstrual regularity (OR 4.03) and reduced waist circumference (MD -2.38), fasting glucose (MD -0.13), and fasting insulin (MD -6.08) compared to minimal or no treatment.
Key findings
- Lifestyle interventions increased the likelihood of achieving regular menstrual cycles (OR 4.03).
- Participants experienced a mean reduction in waist circumference of -2.38 cm.
- Fasting glucose levels decreased by a mean difference of -0.13 mmol/L.
- Fasting insulin levels were reduced by a mean difference of -6.08 µU/mL.
Why it matters
The findings underscore the importance of lifestyle interventions as a first-line treatment for PMOS, highlighting their role in improving reproductive and metabolic health outcomes. Clinicians can tailor these interventions to meet individual patient needs.
What to keep in mind
The review noted high between-study heterogeneity in pooled estimates across many outcomes.