Intrauterine infusion of autologous platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor (G-CSF) prior to single frozen blastocyst transfer in women with thin endometrium: a study protocol for a multicentre sequential multiple assignment randomised trial.

In 30 seconds

This multicentre randomized controlled trial aims to compare the effectiveness of intrauterine infusion of autologous platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor (G-CSF) in women with thin endometrium (TE) undergoing single frozen blastocyst transfer. The study will recruit 440 participants with endometrial thickness <8 mm, assessing live birth rates as the primary outcome.

Key findings

• The primary outcome is the live birth rate from the first embryo transfer.
• Participants will be randomly assigned to receive PRP, G-CSF, or a sham procedure.
• Secondary outcomes include changes in endometrial thickness and clinical pregnancy rates.
• The study employs a triple-blind, sequential multiple assignment randomised trial design.

Why it matters

Understanding the comparative effectiveness of PRP and G-CSF in improving live birth rates in women with thin endometrium could inform treatment strategies and enhance reproductive outcomes in this population.